We can provide Alzheimer’s disease tissue with the following criteria and specifications:
|Tissue Types||Dissection of specific brain regions including; Cortex, Cerebellum, Hippocampus, Frontal Lobe, Pituitary Gland.
Tissue available from any brain region and also some neural tissue samples.
|Braak Stage||Braak stage 0 – without any neurofibrillary changes of Alzheimer’s disease type.
Braak Stage 1 – Braak stage 1 is the point at which tau protein starts to clump into tau tangles.
Braak Stage 2 – Tau tangles have accumulated further and have caused some neurons to burst apart and die.
Braak Stage 3 – Tau tangles and neuronal death have likely caused some memory impairment.
Braak Stage 4 – Tau tangles are beginning to form in the outer layers of the cerebral cortex.
Braak Stage 5 – Tau tangles have caused extensive neuronal death, giving rise to severe memory and cognitive impairment.
Braak Stage 6 – Tau tangles have formed extensively throughout the brain and have caused extensive neuronal death
|Clinical Data||Standard Demographics, Clinical Diagnosis Confirmation from a board-certified Neuropathologist. Specific pathology features such as tau pathology, Neurofibrillary tangles, and Lewy bodies, Braaks confirmation, Medical History, Cause of Death, Serology Results.|
|Associated Samples*||Normal control donors (age and sex matched), CSF, Plasma/Serum, PBMCs.|